Pharmacophore Modeling of N1-alkyltheobromine as Histamine-H1 Receptor Antagonist
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منابع مشابه
A novel membrane sensor for histamine H1-receptor antagonist "fexofenadine".
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Human histamine H1 receptor (HHR1) is a G protein-coupled receptor and a primary target for antiallergic therapy. Here, the ligand-based three-dimensional pharmacophore models were built from a set of known HHR1 inverse agonists using HypoGen module of CATALYST software. All ten generated pharmacophore models consist of five essential features: hydrogen bond acceptor, ring aromatic, positive io...
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ژورنال
عنوان ژورنال: International Journal of Modeling and Optimization
سال: 2015
ISSN: 2010-3697
DOI: 10.7763/ijmo.2015.v5.443